Full text available in english in Adobe Acrobat format:https://www.food.actapol.net/volume9/issue2/10_2_2010.pdf
Issue 9 (2) 2010 pp. 237-241
Mieczysław Walczak1, Beata Pawlus1,2, Andrzej Kędzia3, Jarosław Walkowiak3,4
1Pomeranian Medical University in Szczecin
2Holy Family of Gynecology and Obstetrics in Warsaw
3Poznań University of Medical Sciences
4Poznań University of Life Sciences
2Holy Family of Gynecology and Obstetrics in Warsaw
3Poznań University of Medical Sciences
4Poznań University of Life Sciences
Active synthesis of epidermal growth factor in human mammary glands
Abstract
Background. Human milk contains considerable number of growth factors, including epidermal growth factor (EGF) and insulin-like growth factor-1 (IGF-1). There are no data comparing the EGF and IGF-1 levels in the serum and milk of breast-feeding women. Therefore, the aim of our study was to assess a possible relationship between the concentrations of these growth factors.
Material and methods. Thirty-nine women in child-birth were included in the study.
All women provided blood and milk samples during the first six hours after delivery. EGF (by immunoenzymatic method) and IGF-1 (by radioimmunossay method) concentrations were measured in both media.
All women provided blood and milk samples during the first six hours after delivery. EGF (by immunoenzymatic method) and IGF-1 (by radioimmunossay method) concentrations were measured in both media.
Results. EGF breast milk concentrations ranged from 3.18 to 4.51 ng/ml and on average were significantly higher (p < 0.0001) than those found in the women’s serum (from 0.02 to 0.13 ng/ml). The opposite distribution was found for IGF-1 levels. Its milk concentrations ranged from 8.8 to 61.9 ng/ml and on average were significantly lower (p < 0.0001) than the serum concentrations (from 192.6 to 595.3 ng/ml). No correlation was found between the serum and milk concentrations of both growth factors.
Conclusion. EGF seems to be synthesized locally in mammary glands, whereas IGF-1 probably permeates into the milk from the vascular bed.
Keywords: epidermal growth factor, insulin-like growth factor-1, human milk, serum
Full text available in english in Adobe Acrobat format:https://www.food.actapol.net/volume9/issue2/10_2_2010.pdf
For citation:
| MLA | Walczak, Mieczysław, et al. "Active synthesis of epidermal growth factor in human mammary glands." Acta Sci.Pol. Technol. Aliment. 9.2 (2010): 237-241. |
| APA | Walczak M., Pawlus B., Kędzia A., Walkowiak J. (2010). Active synthesis of epidermal growth factor in human mammary glands. Acta Sci.Pol. Technol. Aliment. 9 (2), 237-241 |
| ISO 690 | WALCZAK, Mieczysław, et al. Active synthesis of epidermal growth factor in human mammary glands. Acta Sci.Pol. Technol. Aliment., 2010, 9.2: 237-241. |